There was a statistically significant difference between Pheo, HNPGL and paragangliomas in other locations according to SDHD mutation presence (P<0.029), malignancy potential according to PASS (over 3 or equal and lower 3) (P<0.0002) and, Ki-67 index (over 3 or equal and lower 3) (P<0.0007) (Table 2). This evidence concerns the gene SDHD and paraganglioma.