High-risk· Personal history of invasive breast cancer· Lobular Carcinoma In Situ (LCIS) and Ductal Carcinoma In Situ (DCIS)· Benign breast disease with atypical hyperplasia· Ionising radiation from treatment of breast cancer, Hodgkin’s disease, etc.· Carrier of BRCA1 and 2 genetic mutation· Significant family history i.e. first-degree family with breast cancer( MRI screening should not be performed in patients with lobular carcinoma in situ and atypical hyperplasia). The gene discussed is BRCA1; the disease is breast lobular carcinoma.