Interestingly, elevated plasma concentration of two ADAM17 substrates such as TNFR1 and TNFR2 have been recently found to predict Stage 3 Chronic Kidney Disease and End Stage Renal Disease in patients with type 1 and type 2 diabetes, respectively, even in the absence of proteinuria [22, 23]. This evidence concerns the gene TNFRSF1A and chronic kidney disease.