ADAM17 and Nephropathy: Recently, it has been demonstrated that shedding of renal ACE2 into urine is increased in db/db diabetic mice similar to the expression of ADAM17 in the kidney [27]: due to the action of ADAM17, proteolytically active form of ACE2 are shed from the kidney into urine of db/db mice, and this loss of the renoprotective enzyme ACE2 could contribute to kidney damage [27].