While AE develops within minutes due to sudden mechanical stress [1, 52], chronic emphysema develops over several years due to a variety of causes (e.g., senile emphysema [53–55], chronic obstructive pulmonary disease (COPD) [56], alpha-1-antitrypsin deficiency [57], or other secondary forms [58]). This evidence concerns the gene SERPINA1 and chronic obstructive pulmonary disease.