APOE and Mental deterioration: Linear mixed-effects models showed that age (t = −2.28; P = .02), but not sex (t = 0.92; P = .36) or APOE genotype (t = 1.06; P = .29), modified the association between baseline [18F]flortaucipir temporal meta-ROI SUVR and MMSE change, because older individuals showed faster cognitive decline at similar tau PET levels (Figure 3).