CXCR4 and nonpapillary renal cell carcinoma: Also, the Western Blot analysis was conducted, and the results supported that CXCR4 positively regulated N-cadherin and Vimentin (Figure 3(c,d)), while negatively regulated E-cadherin (Figure S2A-B) to promote epithelial-mesenchymal transition (EMT) in ccRCC cells.