Here, the ccRCC cells (SW839 and OSRC-2) were exposed to DDP (30 μg/ml) for 0 h, 12 h, 24 h, 36 h and 48 h, and were divided into four groups, including Control, DDP group, DDP + OE-CXCR4 group, and DDP + KD-CXCR4 group. The gene discussed is CXCR4; the disease is nonpapillary renal cell carcinoma.