Among all the genes, the chemokine CXC receptor 4 (CXCR4) is identified as an oncogene to facilitate the development of multiple cancers [13–17], and recent data indicate that CXCR4 was closely related to patients’ prognosis in ccRCC [21–24], but its role in regulating RCC development and the potential underlying mechanisms have not been investigated in the available publications. This evidence concerns the gene CXCR4 and nonpapillary renal cell carcinoma.