PECAM1 and neoplasm: Experiments demonstrated that tumor weights, volumes, and growth were significantly reduced by PTX-PNS treatment concerning PTX; the angiogenesis and the cell proliferation, detected in the tumor samples with CD31 and Ki-67 antibodies, respectively, indicated that, in the PTX-PNS-treated tumors, the tube formation was inhibited, and a low amount of proliferating cells was present (Clemente et al., 2019).