Indeed, prior work indicated that the ISR/UPR and eIF2α phosphorylation can regulate cancer cell fate, depending on the nature of the stress and metabolic state (Blagden and Willis, 2011; Chiti and Dobson, 2006; Darini et al., 2019; Guo et al., 2017; Kim et al., 2015; Koromilas, 2015; Kouroku et al., 2007; Nam and Jeon, 2019; Pakos-Zebrucka et al., 2016; Travers et al., 2000; Yoshida et al., 2001a; Yoshida et al., 2001b). Here, EIF2A is linked to cancer.