ATF6 and breast carcinoma: As shown in Figure 7B, the abundance of the ATF6 full-length isoform declined in the presence of DTT, which activates each branch of the UPR, but was unchanged between the MAL3-101 sensitive (MCF7 and MDA MB 231) and resistant (MDA MB 453 and MDA MB 361) breast cancer cells after MAL3-101 treatment.