A number of epigenome-wide association studies in Alzheimer’s disease patients consistently report neuropathology-associated DNA hypermethylation of ANK1 (De Jager et al., 2014; Higham et al., 2019; Lunnon et al., 2014; Smith et al., 2019a; Smith et al., 2019b). Here, ANK1 is linked to early-onset autosomal dominant Alzheimer disease.