Intriguingly, case studies of patients with hereditary spherocytic anemia, caused by mutations in AnkR, report various neurological disturbances (Coetzer et al., 1988; McCann and Jacob, 1976; Miya et al., 2012), and a number of recent epigenome-wide association studies in Alzheimer’s disease have consistently found neuropathology-associated DNA hypermethylation of ANK1 (ANK1 is the gene encoding AnkR) (De Jager et al., 2014; Gasparoni et al., 2018; Higham et al., 2019; Lunnon et al., 2014; Smith et al., 2019a; Smith et al., 2019b). The gene discussed is ANK1; the disease is early-onset autosomal dominant Alzheimer disease.