To determine the role of neuronal AnkR and confirm its high expression in interneurons, we constructed a floxed allele for Ank1 (Ank1F/F; Figure 1F); this new model allows for an exploration of AnkR function in the brain while avoiding the confound of anemia due to loss of AnkR from red blood cells. This evidence concerns the gene ANK1 and anemia (phenotype).