An intron polymorphism of β‐catenin cofactor TCF7L2 is related to increased risk of type II diabetes (T2DM).[6] Gene polymorphisms of Wnt coreceptor LRP6 are also associated with T2DM,[7] hyperlipidemia;[8] atherosclerosis,[9] and even LOAD.[10] These findings suggest that defective Wnt signaling in the brain may play an important link between altered fuel metabolism and early LOAD pathogenesis. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.