Likewise, our results showed that overexpression of miR‐29b‐2‐5p or miR‐34c‐3p could inhibit TGF‐β1 induced EMT and attenuate silica‐induced pulmonary fibrosis, and combined with these two miRNAs exerted a synergistic effect in vitro and in vivo. The gene discussed is TGFB1; the disease is pulmonary fibrosis.