Besides, PUE is also reported to improve AD‐induced cognitive dysfunction, OS and neuronal apoptosis,26, 27, 72, 76 and PD‐induced behavioral deficits and depletion of dopamine due to loss of dopaminergic neurons 29 by activating the PI3K/Akt signal.29, 72, 76. This evidence concerns the gene AKT1 and Alzheimer disease.