We also reported epigenetic mechanisms of action subserving the dietary effects of HFHS, leading to ovarian granulosa cell ageing and premature ovarian failure by inhibiting endogenous miR‐146, activating the DAB2IP/ASK1/p38‐signalling pathway and inducing γ‐H2A.X phosphorylation modification.13 This evidence concerns the gene MAP3K5 and primary ovarian failure.