Our recent studies have further confirmed some epigenetic mechanisms that underly ovarian granulosa cell ageing and premature ovarian failure due to an HFHS diet, including an inhibition of endogenous miR‐146, activation of the DAB2IP/ASK1/p38‐signalling pathway and induction of γ‐H2A.X phosphorylation.13 Here, MAP3K5 is linked to primary ovarian failure.