While the underlying mechanisms of increased vascular permeability and defective neo‐angiogenesis in diabetes‐related complications are still being explored, the pivotal role of PRKCB2 in regulating endothelial permeability has been well documented in various mammalian model systems (Aiello et al, 1997; Durpès et al, 2015). This evidence concerns the gene PRKCB and diabetes mellitus.