Expression of CDH5, CTNNB1, and PRKCB was checked in the hyperglycemia disease model, and we observed that PRKCB was localized extensively in the membrane, while the signals of CDH5 and CTNNB1 were diffused and not exclusively on the membrane (Fig 7E, F and Q; I, J and R; M, N and S). Here, CTNNB1 is linked to Hyperglycemia.