We next investigated the specificity of ACSNI by comparing our predictions with KLF6 and EPAS1 signals from non-ccRCC cells lines as non-specific controls (including endothelial cells [human umbilical vein endothelial cells—HUVECs] and primary peripheral blood mononuclear cells [PB-CD34+]). This evidence concerns the gene KLF6 and nonpapillary renal cell carcinoma.