In this section, we present classification results for five binomial TCGA cancer dataset comparisons: kidney renal clear cell carcinoma (KIRC) versus kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD) versus lung squamous cell carcinoma (LUSC), breast invasive carcinoma (BRCA) versus matched normal breast tissue (normal), estrogen receptor positive (ERpos) versus estrogen receptor negative (ERneg) breast cancers, and luminal A (LumA) versus luminal B (LumB) breast cancers. This evidence concerns the gene ESR1 and breast cancer.