At the time of our semantic search of the PMC database, hepatocyte growth factor (HGF) and retinoblastoma-associated protein 1 (E2F1) were implicated in the greatest number of published breast cancer papers (6,356 and 5,925, respectively) among all of the 44 genes queried (see Table S7). The gene discussed is E2F1; the disease is breast carcinoma.