The glycocalyx is described as a macromolecular sieve that regulates molecular and fluid trans vascular flux.6,7 It is well known that in pathological conditions, like sepsis, atherosclerosis, and kidney disease, the glycocalyx is damaged resulting in vascular hyperpermeability and increased apoptosis.8–11 Heparanase, a HS degrading enzyme, is frequently associated with glycocalyx damage. Here, HPSE is linked to Sepsis.