Finally, we did DNA sequencing in peripheral blood, and analyzed MDS related mutant genes, comparing JUN with two of its founder strains (C57BL/6J and NOD) and two other CC strains (NUK and LOT), and found that there was a deletion and an insertion mutation of the Rps14 gene in the qA2 region of chromosome 18. The gene discussed is RPS14; the disease is myelodysplastic syndrome.