Enriched canonical pathways mainly belonged to two biological processes: 1) the junction/connection including G6P signaling, osteoarthritis signaling, and ILK signaling pathways; and 2) the inflammation/proliferation including PDGF signaling, CXCR4 signaling, actin cytoskeleton signaling, and NF-κB signaling. Here, CXCR4 is linked to osteoarthritis.