Moreover, it is suggested that increased tissue sensitivity to cortisol due to polymorphisms in glucocorticoid receptor (GR) gene (NR3C1, Nuclear Receptor Subfamily 3 Group C Member 1) is related to the criteria of MetS (e.g., visceral obesity, hypertension), despite normal HPA axis activity [8,41]. The gene discussed is NR3C1; the disease is Hypertension.