Analysis of the TCGA-CRC dataset (TCGA Provisional, cBioPortal) revealed a low mutation (2.73%) and CNA (amplification, 3.18%; deep deletion, 0.00%) frequency in CRC (Figure 4b), and no association was found between CNA status of ADHFE1 and transcriptional expression (all P > 0.05, Figure 4c). The gene discussed is ADHFE1; the disease is colorectal carcinoma.