For example, EGFR/SRC/ERK signaling-stabilized YTHDF2 (YTH N6-methyladenosine RNA binding protein 2) protein promoted cholesterol dysregulation and facilitated tumorigenesis of GBM cells (15); knockdown of methyltransferase like 14 (METTL14) limited cholesterol efflux (16). The gene discussed is METTL14; the disease is glioblastoma.