The renin–angiotensin–aldosterone system (RAAS), also referred to as the angiotensin (Ang)-converting enzyme/Ang II/Ang type 1 receptor axis, is altered following cerebrovascular injuries such as stroke and BCAS-induced hypoperfusion and is known to induce injury in various organs, affecting cardiac function, renal function, as well as cognitive function (32, 82, 83). This evidence concerns the gene AGT and stroke disorder.