CACYBP and neoplasm: In 2001, Matsuzawa et al. studied the process of β-catenin degradation induced by p53 activation in tumor cells, and found a new SAIH-1 binding protein (SIP), which can bind with SAIH-1, SKPL, EBI, etc., to form a complex, and eventually ubiquitinate to degrade β-catenin (Matsuzawa and Reed, 2001).