Both endocrine and exocrine tissue are affected in type 1 diabetes (T1D) (Rodriguez-Calvo et al., 2014; Campbell-Thompson et al., 2015; Alexandre-Heymann et al., 2019; Bender et al., 2020), but the disease is characterized by a chronic autoimmune destruction of insulin-producing beta cells (Rowe et al., 2011). Here, INS is linked to type 1 diabetes mellitus.