SPTBN2 and neoplasm: Therefore, we have identified that miRNA-1827 as a novel biomarker is associated with the proliferation and prognosis of OV by targeting SPTBN2 and BCL2L1. These hub genes are determined to be involved in the tumor immunomodulatory process mediated by CCL27 and CCR10. On the whole, miRNA-1827 from computational biology analysis exerts promising effects as an intervention target in OV management in future applications.