SIN inhibits proliferation, invasion, and migration and promotes apoptosis in cancer cells by modulating signaling pathways and microRNAs, such as PI3K/AKT/Wnt signaling pathway, SHh pathway, and miR-23a (Song et al., 2018; Liu et al., 2019; Xu et al., 2019). The gene discussed is AKT1; the disease is cancer.