All results in this study indicated that the effect of SIN in inhibiting proliferation and inducing apoptosis in HCC cells is based on inhibition of MARCH1, resulting in down-regulating AMPK/STAT3 signaling pathway and downstream molecules, CyclinD1, CyclinB1, Mcl-1, Bax, and Bcl-2 (Figure 5E). Here, CCND1 is linked to hepatocellular carcinoma.