MARCH1 downregulation induced by siRNA or drugs could inhibit the progression of HCC by down-regulating PI3K-AKT-β-catenin and PTEN/AKT signaling pathways (Xie et al., 2019a; Xie et al., 2019b; Dai et al., 2020). This evidence concerns the gene MARCHF1 and hepatocellular carcinoma.