Some experimental studies indicate that SIN is useful for the treatment of gastric carcinoma, lung cancer and breast cancer through regulating PI3K/AKT/Wnt, JAK/STAT3, JNK, and MEK/ERK signaling pathways (Jiang et al., 2016; Gao et al., 2019; Liu et al., 2019). This evidence concerns the gene STAT3 and lung carcinoma.