Also, the reduction of CyclinD1 and CyclinB1 in HCC cells treated with SIN is in agreement with a previous study, in which CyclinD1 and CyclinB1 down-regulation promoted cells exit from G2/M and enter into G0/G1 phase (Wang et al., 2018). The gene discussed is CCND1; the disease is hepatocellular carcinoma.