It has been reported that in sarcoma (Miyamoto et al., 2016), pancreatic cancer (Kurozumi et al., 2016) and breast cancer (Dong et al., 2005), HIF-1α can regulate the expression of PLOD2 and thus affect tumor migration and invasion ability (Rajkumar et al., 2011). This evidence concerns the gene PLOD2 and neoplasm.