TNF and renal cell carcinoma: Finally, the RNA-seq data showed that typical pathways involved in RCC development and progression such as “Lysine degradation,” “VEGF signaling pathway,” “Transcriptional misregulation in cancer,” “Renal cell carcinoma,” “MAPK signaling pathway,” “TNF signaling pathway,” and “Metabolic pathways” were enriched by KEGG pathway analysis.