TNF and hereditary clear cell renal cell carcinoma: These differentially expressed genes were further categorized based on the KEGG pathway, and we found they were associated with “Lysine degradation,” “VEGF signaling pathway,” “Transcriptional misregulation in cancer,” “Renal cell carcinoma,” “MAPK signaling pathway,” “TNF signaling pathway,” and “Metabolic pathways” in two RCC cell lines related with PLOD2 demethylation (Figures 7E,F).