Specifically, tumor cells modulate the recruitment of tumor-associated macrophages (TAMs), T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSc) in the tumour microenvironment (Kitamura et al., 2015), thus suppressing the cytotoxic function of natural killer (NK) cells and CD8+ T cells through the expression of molecules such as programmed cell death ligand 1 (PDL1) and promoting tumor survival and metastatic potential (Kitamura et al., 2015). This evidence concerns the gene CD274 and neoplasm.