STAT1 and cancer: HNRNPC overexpression was observed in a variety of human cancers, including lung cancer (Park et al., 2012) HNRNPC, as a protein-coding gene, could also interact with KHSRP to activate the IFN-α-JAK-p-STAT1 signaling pathway and promoted NSCLC cell proliferation, migration, and invasion (Yan et al., 2019).