NUMB and non-small cell lung carcinoma: For instance, QKI was shown to one of the most downregulated splicing factors in NSCLC, while QKI-5 was able to competitively bind to NUMB with SF1 protein to induce the NUMB exon 11 skip and, therefore, inhibited the Notch signaling (Zong et al., 2014; de Miguel et al., 2016).