Xu et al. (2019) has reported that MiR-451a/BAP31 axis can inhibit cell proliferation and increase apoptosis via inducing ER stress in colorectal cancer. As cancer-testis antigen, BAP31 DNA vaccines exert potent anti-tumor activity in therapeutic model using B16 melanoma cells (Yu et al., 2015). One recent study has investigated that BAP31 may promote HCC cell proliferation by stabilizing SERPINE2 (Zhang et al., 2020). This evidence concerns the gene BCAP31 and hepatocellular carcinoma.