ACE2 and COVID-19: Some studies have reported that interferon-mediated induction of ACE2 expression occurs upon SARS-CoV-2 infection (Fu et al., 2020; Su and Jiang, 2020; Tan et al., 2020), suggesting that blocking HS-SV2-S binding by heparin may not be sufficient (Efendizade et al., 2020; Hippensteel et al., 2020; Menezes-Rodrigues et al., 2020) and would need to be combined with other mechanism-based agents to most effectively to treat and/or prevent COVID-19.