Previous studies have suggested multiple molecular pathways related to oxidative stress that is involved in NAFLD, including IRs-1/Akt, CYP2E1/JNK, SIRT1/SIRT3-FOXO3a, A(10)MPK/Nrf2, Nrf2/HO-1, and AMPK signaling pathways (10–13). This evidence concerns the gene HMOX1 and metabolic dysfunction-associated steatotic liver disease.