In the inherited renal tubular disorders, uEVs have been used as a non-invasive tool to detect the defect of mutated renal tubular transporter such as NCC and Na+/K+/2Cl− cotransporter (NKCC2) expression in patients with GS and Bartter syndrome, respectively (17, 18). This evidence concerns the gene SLC12A1 and renal tubule disorder.