Our analysis showed that peak (nadir) liver function markers were commonly correlated with the direct or indirect markers of inflammation (C-reactive protein, lactate dehydrogenase, platelet count, hemoglobin at baseline), which support the point that most cases of liver derangement may reflect sepsis related cholestasis and inflammatory changes, or hepatotoxicity from concomitant medications (41, 42). Here, CRP is linked to cholestasis.