GSTM1 and capillary leak syndrome: We utilized the large size of erythrocytes, which cannot extravasate in spite of massively increased vascular permeability, and used dynamic changes in Hb concentrations over a 24 h period after resuscitation as a surrogate parameter for the degree of vascular permeability, as suggested by data from capillary leak syndrome or burn injury (8–12, 17, 18).