Although CREB1 has been implicated in the physiology of nerve and most recently in some cancer cells by cooperating with some protein kinases or small molecules, including PKA, PKB (AKT), MAPK, cAMP, and Ca2+ to inhibit apoptosis and promote cell survival in unstressed situation (Bonni and Brunet, 1999; Shankar et al., 2005; Chhabra et al., 2007; Pigazzi et al., 2007; Aggarwal et al., 2008; Shukla et al., 2009), whether CREB families play a role in modulating tumor cellular metabolism remains unknown. Here, AKT1 is linked to cancer.