In a mouse model of ischemic stroke, S100A11 exerts neuroprotective effects, and upregulation of S100A11 protected against neuronal apoptosis by interaction with ANXA1 through the nuclear translocation signal (NTS) of ANXA1, thereby blocking ANXA1 nuclear translocation (Xia et al., 2018). Here, S100A11 is linked to ischemic stroke.