Given that ARNT is a master regulator of angiogenesis (Su et al., 2015; Ji et al., 2019), its diminished expression in the endothelium in the setting of diabetes may explain why diabetes is the biggest risk factor leading to vascular endothelial dysfunction and delayed tissue repair and regeneration, which eventually manifests as severe vascular complications in diabetic patients (Hadi and Suwaidi, 2007; Severino et al., 2018; Knapp et al., 2019). Here, ARNT is linked to diabetes mellitus.