Mariusz and co-workers demonstrated that LCN2 was significantly upregulated in the mouse hippocampus after stress, which resulted in the loss of dendritic spines and regulation of neuronal excitability (as a result of reduced dendritic spine actin mobility), and increased anxiety (Pawlak et al., 2003; Adhikari et al., 2010; Mucha et al., 2011). This evidence concerns the gene LCN2 and Anxiety.