BRD4 and thyroid cancer: Importantly, treatment of thyroid cancer cells with BRD4 inhibitor JQ1 significantly downregulated the expression of PLXNC1 and some PTC-specific genes, while the histone deacetylase inhibitors (HDACi) SAHA treatment induced robust increases of CD36 and TRPC6 expressions in thyroid cancer cell lines (Figure 5G and Supplementary Figure 3).