Importantly, treatment of thyroid cancer cells with BRD4 inhibitor JQ1 significantly downregulated the expression of PLXNC1 and some PTC-specific genes, while the histone deacetylase inhibitors (HDACi) SAHA treatment induced robust increases of CD36 and TRPC6 expressions in thyroid cancer cell lines (Figure 5G and Supplementary Figure 3). Here, BRD4 is linked to thyroid gland carcinoma.