CD274 and neoplasm: In glioma, HH signaling can recruit tumor-associated macrophages (TAMs) and can cause the immunosuppression MDSCs by releasing C-C motif chemokine ligand (CCL) 2/3 (Mi et al., 2020), thereby inducing PD-L1 expression, inducing stromal cells to produce IL10, and promoting the transcription factor forkhead box P3 (FOXP3) expression in Tregs (Grund-Groschke et al., 2019).