CCN1 and neoplasm: Interestingly, a recent study from Lechertier et al. (2020) show that loss of PC FAK enhances p-Pyk2-Gas6-Axl-Akt signaling and its downstream Cyr61 expression to stimulate tumor angiogenesis, while PC-derived Cyr61 is also able to enhance tissue factor expression in tumor cells and its mediated cell proliferation.