Anti-angiogenetic therapy is recognized as a promising treatment strategy for cancer, while many anti-angiogenic drugs have been approved for certain types of cancers, including anti-vascular endothelial growth factor (VEGF) drug (i.e., Bevacizumab, Ranibizumab) and some tyrosine kinase inhibitors (i.e., Sorafenib, Sunitinib) (Meng et al., 2015; Ramjiawan et al., 2017; Li et al., 2018). This evidence concerns the gene VEGFA and cancer.