In a mouse spontaneous model of pancreatic cancer (RIP1-Tag5), knocking out RGS5 (regulator of G-protein signaling 5) gene results in PC maturation, vascular normalization and consequently a marked reduction in tumor hypoxia and vessel leakiness, while these changes enhance immune cell infiltration and extend the survival of tumor bearing mice (Hamzah et al., 2008). Here, RGS5 is linked to neoplasm.