EIF2AK2 and ocular toxoplasmosis: These findings have in vivo relevance because Beclin 1-deficient mice (BECN1±), mice with deficiency of ATG7 in myeloid cells (Atg7flox/flox-Lyz-M Cre mice) and mice deficient in PKR (PKR–/–), exhibited increased susceptibility to cerebral and ocular toxoplasmosis (Portillo et al., 2010; Ogolla et al., 2013).