The likely mechanisms of protection against cerebral and ocular toxoplasmosis identified in mice are as follows: (i) CD40-induced toxoplasmacidal activity in macrophages/microglia (Reichmann et al., 2000; Portillo et al., 2010); (ii) recently identified induction of toxoplasmacidal activity in neural endothelial cells accompanied by reduced invasion of the brain and retina by the parasite (Portillo et al., 2019); (iii) reduced anti-T. The gene discussed is CD40; the disease is ocular toxoplasmosis.