From our heatmap (Figure 2A), we observed that “readers” (IGFBP3, IGFBP1, HNRNPA2B1, YTHDF1, FMR1, HNRNPC, RBMX) and “writers” (VIRMA, METTL3, METTL16, RBM15, WTAP) were upregulated in the HNSCC samples, compared to the controls. This evidence concerns the gene METTL3 and head and neck squamous cell carcinoma.