From our heatmap (Figure 2A), we observed that “readers” (IGFBP3, IGFBP1, HNRNPA2B1, YTHDF1, FMR1, HNRNPC, RBMX) and “writers” (VIRMA, METTL3, METTL16, RBM15, WTAP) were upregulated in the HNSCC samples, compared to the controls. The gene discussed is IGFBP1; the disease is head and neck squamous cell carcinoma.