The PI3K pathway activated by IGF1R usually alters in cancer cells (Cairns et al., 2011), which not only provides anti-apoptotic and mitogenic signals but also affects cancer cell metabolism, in this process, Akt, the downstream target of PI3K, has been shown to stimulate the glycolytic pathway, favoring energy production in the tumors (Plas and Thompson, 2005). Here, IGF1R is linked to cancer.