IGF1 and cancer: Based on these effects, many studies have reported its role in cancers, such as prostate, lung, colorectal, ovarian cancer, breast cancer, thyroid cancer, and liver cancer (Gunnell et al., 2001; Lango Allen et al., 2010; Chhabra et al., 2011; Wu and Gao, 2018), indicating that the effects of GH and IGF1 on cell proliferation can not only maintain the growth and development of normal organism, but also promote the process of cancer cells.