Upregulated TFs have enriched in herpes simplex virus type 1 infection, transcriptional misregulation in cancer, TGF-β signaling pathway, maturity onset diabetes of the young, and Cellular senescence, while downregulated TFs are enriched in herpes simplex virus type 1 infection, transcriptional misregulation in cancer, maturity onset diabetes of the young, parathyroid hormone synthesis, secretion, and action, Th17 cell differentiation (Figures 2E,F). The gene discussed is PTH; the disease is cancer.