One way APOE genotype could impact neuronal function is through neurovascular disruption, which is found with APOE4 during aging, in Alzheimer’s disease and in respective mouse models (Salloway et al., 2002; Zipser et al., 2007; Poels et al., 2010; Halliday et al., 2013; Zlokovic, 2013; Halliday et al., 2015; Tai et al., 2016; Thomas et al., 2016; Marottoli et al., 2017; Tai et al., 2017; Thomas et al., 2017). The gene discussed is APOE; the disease is Alzheimer disease.