MCM4 and neoplasm: Surprisingly, the MCM4 expression was also found to be associated with MCM4 copy number (p < 0.001; Figure 4C), higher metastasis potential (p < 0.001; Figure 4D), tumor mitotic count (p < 0.001; Figure 4E), and worse survival outcome (p = 0.019; Figure 4F), but not tumor necrosis rate (Supplementary Figure 6A).