PDE4D and myocardial infarction: lncRNA Xist, which positively mediates PDE4D expression via interacting miR-130a-3p (Zhou et al., 2019d) and targets miR-101a-3p through regulating FOS (Lin B. et al., 2020), promotes myocardial infarction development and cell apoptosis, and inhibits cell proliferation though the miR-130a-3p/PDE4D aixs and miR-101a-3p/FOS aixs.