lncRNA Xist, which acts as a molecular sponge of miR-101, miR-497, miR-185, and miR-337 to mediate EZH2, MACC1, TGF-β1, and JAK2 expression, is involved in gastric cancer progression through mediating miR-101/EZH2 axis, miR-497/MACC1 axis, miR-185/TGF-β1 axis, and miR-337/JAK2 axis (Chen D.L. et al., 2016; Ma L. et al., 2017; Zhang Q. et al., 2018; Zheng W. et al., 2020). The gene discussed is MACC1; the disease is gastric cancer.