Analogously, lncRNA Xist, which is highly expressed in nasopharyngeal carcinoma tissues and cell lines, facilitates nasopharyngeal carcinoma development via activating miR-34a-5p/E2F3, miR-148a-3p/ADAM17, and miR-381-3p/NEK5 axis (Song et al., 2016; Shi et al., 2020; Zhao C.H. et al., 2020). This evidence concerns the gene E2F3 and nasopharyngeal carcinoma.