In neuroblastoma (Zhang et al., 2019a), lncRNA Xist, which interacts with EZH2 to downregulate DKK1 by inducing H3 histone methylation, promotes neuroblastoma cell growth, proliferation, migration, and invasion via modulating H3 histone methylation of DKK1 in neuroblastoma. Here, DKK1 is linked to neuroblastoma.